InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptgs2

Summary

InnateDB Protein

IDBP-197329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptgs2

Protein Name

prostaglandin-endoperoxide synthase 2

Synonyms

Cox-2; COX2; PGHS-2; Pghs2; PHS-2; TIS10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035065

InnateDB Gene

IDBG-197327 (Ptgs2)

Protein Structure

UniProt Annotation

Function

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis. {ECO:0000269PubMed:12925531, ECO:0000269PubMed:20463020, ECO:0000269PubMed:20810665, ECO:0000269PubMed:21489986, ECO:0000269PubMed:22465430}.

Subcellular Localization

Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Following colon injury, expressed in the wound bed mesenchyme during the first phase of repair, probably by colonic mesenchymal stem cells (at protein level). {ECO:0000269PubMed:22465430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	6 [view]
Protein-DNA	10 [view]
Protein-RNA	2 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0004666	prostaglandin-endoperoxide synthase activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0001525	angiogenesis
GO:0006954	inflammatory response
GO:0006979	response to oxidative stress
GO:0007566	embryo implantation
GO:0007612	learning
GO:0007613	memory
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009314	response to radiation
GO:0009750	response to fructose
GO:0010033	response to organic substance
GO:0010042	response to manganese ion
GO:0010226	response to lithium ion
GO:0010243	response to organonitrogen compound
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010942	positive regulation of cell death
GO:0014070	response to organic cyclic compound
GO:0019233	sensory perception of pain
GO:0019371	cyclooxygenase pathway
GO:0030216	keratinocyte differentiation
GO:0030282	bone mineralization
GO:0030728	ovulation
GO:0031622	positive regulation of fever generation
GO:0031915	positive regulation of synaptic plasticity
GO:0032227	negative regulation of synaptic transmission, dopaminergic
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0033280	response to vitamin D
GO:0034097	response to cytokine
GO:0034612	response to tumor necrosis factor
GO:0034644	cellular response to UV
GO:0035633	maintenance of blood-brain barrier
GO:0042127	regulation of cell proliferation
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0042493	response to drug
GO:0042633	hair cycle
GO:0042640	anagen
GO:0043065	positive regulation of apoptotic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045786	negative regulation of cell cycle
GO:0045907	positive regulation of vasoconstriction
GO:0045986	negative regulation of smooth muscle contraction
GO:0045987	positive regulation of smooth muscle contraction
GO:0046697	decidualization
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050873	brown fat cell differentiation
GO:0051384	response to glucocorticoid
GO:0051926	negative regulation of calcium ion transport
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0055114	oxidation-reduction process
GO:0070542	response to fatty acid
GO:0071260	cellular response to mechanical stimulus
GO:0071318	cellular response to ATP
GO:0071456	cellular response to hypoxia
GO:0071636	positive regulation of transforming growth factor beta production
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis
GO:0090271	positive regulation of fibroblast growth factor production
GO:0090336	positive regulation of brown fat cell differentiation
GO:0090362	positive regulation of platelet-derived growth factor production