InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pnrc2

Summary

InnateDB Protein

IDBP-197341.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pnrc2

Protein Name

proline-rich nuclear receptor coactivator 2

Synonyms

0610011E17Rik; D4Bwg0593e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030436

InnateDB Gene

IDBG-197339 (Pnrc2)

Protein Structure

UniProt Annotation

Function

Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}.

Disease Associations

Tissue Specificity

Strong expression is detected in lung, spleen, ovary, thymus, and colon. {ECO:0000269PubMed:16181749}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated