Version 5.4
Mus musculus Protein: Snai3
Summary
InnateDB Protein IDBP-197353.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Snai3
Protein Name snail homolog 3 (Drosophila)
Synonyms AI643946; Smuc; Zfp293;
Species Mus musculus
Ensembl Protein ENSMUSP00000006762
InnateDB Gene IDBG-197351 (Snai3)
Protein Structure
UniProt Annotation
Function Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3'. {ECO:0000269PubMed:10606664}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10606664}.
Disease Associations
Tissue Specificity Highly expressed in skeletal muscle and thymus. Lower expression in heart, lung and spleen. {ECO:0000269PubMed:10606664}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Protein Structure and Domains
PDB ID MGI:1353563
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QY31
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 30927
UniGene Mm.103673
RefSeq NP_038942
MGI ID
MGI Symbol Snai3
OMIM
CCDS CCDS22739
HPRD
IMGT
EMBL AF133714 AF195655 AK042234 AK089285 AK153633 AK154585 BC100724 BC100726 BC100727
GenPept AAF22956 AAI00725 AAI00727 AAI00728 AAQ13827 BAC31201 BAC40828 BAE32128 BAE32693

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca