InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccbl2

Summary

InnateDB Protein

IDBP-197364.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccbl2

Protein Name

cysteine conjugate-beta lyase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000041675

InnateDB Gene

IDBG-197362 (Ccbl2)

Protein Structure

UniProt Annotation

Function

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro). {ECO:0000250, ECO:0000269PubMed:19029248}.

Subcellular Localization

Disease Associations

Tissue Specificity

Widely expressed, with higher expression levels in liver, kidney, heart and neuroendocrine tissues. {ECO:0000269PubMed:16376499}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016212	kynurenine-oxoglutarate transaminase activity
GO:0030170	pyridoxal phosphate binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0047315	kynurenine-glyoxylate transaminase activity
GO:0047804	cysteine-S-conjugate beta-lyase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006520	cellular amino acid metabolic process
GO:0009058	biosynthetic process
GO:0070189	kynurenine metabolic process
GO:0097052	L-kynurenine metabolic process