InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aqr

Summary

InnateDB Protein

IDBP-197372.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aqr

Protein Name

aquarius

Synonyms

AW495846; mKIAA0560;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047157

InnateDB Gene

IDBG-197368 (Aqr)

Protein Structure

UniProt Annotation

Function

Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Localizes to speckle-like regions of the nucleoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0008150	biological_process

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

MGI:1276102

InterPro

IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CFQ3

PhosphoSite

PhosphoSite-Q8CFQ3

TrEMBL

UniProt Splice Variant

Entrez Gene

11834

UniGene

Mm.2545

RefSeq

NP_033832

MGI ID

MGI Symbol

Aqr

OMIM

CCDS

CCDS16565

HPRD

IMGT

EMBL

AK122310 AK145547 AK151716 BC042479 U90333

GenPept

AAB50008 AAH42479 BAC65592 BAE26500 BAE30635