InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nabp2

Summary

InnateDB Protein

IDBP-197455.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nabp2

Protein Name

oligonucleotide/oligosaccharide-binding fold containing 2B

Synonyms

2610036N15Rik; Obfc2b;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026439

InnateDB Gene

IDBG-197453 (Nabp2)

Protein Structure

UniProt Annotation

Function

Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell- cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007093	mitotic cell cycle checkpoint
GO:0010212	response to ionizing radiation