InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nprl2

Summary

InnateDB Protein

IDBP-197548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nprl2

Protein Name

nitrogen permease regulator-like 2 (S. cerevisiae)

Synonyms

2810446G01Rik; G21; NPR2L; Tusc4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010201

InnateDB Gene

IDBG-197546 (Nprl2)

Protein Structure

UniProt Annotation

Function

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. May act as a tumor suppressor (By similarity). As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0033673	negative regulation of kinase activity
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1914482

InterPro

IPR009348 Nitrogen permease regulator 2

PFAM

PF06218

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WUE4

PhosphoSite

PhosphoSite-Q9WUE4

TrEMBL

UniProt Splice Variant

Entrez Gene

56032

UniGene

RefSeq

NP_061367

MGI ID

MGI Symbol

Nprl2

OMIM

CCDS

CCDS23492

HPRD

IMGT

EMBL

AF131207 AK010331 AK013299 BC026548

GenPept

AAD33474 AAH26548 BAB26858 BAB28777