InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hs2st1

Summary

InnateDB Protein

IDBP-197595.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hs2st1

Protein Name

heparan sulfate 2-O-sulfotransferase 1

Synonyms

AW214369; Hs2st; mKIAA0448;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043066

InnateDB Gene

IDBG-197593 (Hs2st1)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme. Mediates 2-O- sulfation of both L-iduronyl and D-glucuronyl residues. {ECO:0000269PubMed:11331020, ECO:0000269PubMed:11457822, ECO:0000269PubMed:9637690}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000269PubMed:11687650}; Single-pass type II membrane protein {ECO:0000269PubMed:11687650}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at higher level in lung and brain. Weakly expressed in spleen. {ECO:0000269PubMed:11331020, ECO:0000269PubMed:9637690}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004394	heparan sulfate 2-O-sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO:0030202	heparin metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0060676	ureteric bud formation