InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tceb3

Summary

InnateDB Protein

IDBP-197601.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tceb3

Protein Name

transcription elongation factor B (SIII), polypeptide 3

Synonyms

110kDa; AA408125; Tceb3a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030427

InnateDB Gene

IDBG-197599 (Tceb3)

Protein Structure

UniProt Annotation

Function

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00649}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1351315

InterPro

IPR001810 F-box domain
IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
IPR010684 RNA polymerase II transcription factor SIII, subunit A
IPR017923 Transcription factor IIS, N-terminal

PFAM

PF00646
PF12937
PF13013
PF06881
PF08711

PRINTS

PIRSF

SMART

SM00256
SM00509

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CB77