InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Id3

Summary

InnateDB Protein

IDBP-197684.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Id3

Protein Name

inhibitor of DNA binding 3

Synonyms

bHLHb25; Hlh462; Idb3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008016

InnateDB Gene

IDBG-197682 (Id3)

Protein Structure

UniProt Annotation

Function

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. {ECO:0000269PubMed:19217292, ECO:0000269PubMed:22862948, ECO:0000269PubMed:23824195}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981, ECO:0000269PubMed:16556596}. Cytoplasm {ECO:0000269PubMed:16556596}. Note=Nuclear in proliferating cells, translocates to cytosol during cell differentiation.

Disease Associations

Tissue Specificity

Expressed by myoblasts (at protein level). {ECO:0000269PubMed:23824195}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	13 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001656	metanephros development
GO:0006275	regulation of DNA replication
GO:0006351	transcription, DNA-templated
GO:0007417	central nervous system development
GO:0007507	heart development
GO:0007517	muscle organ development
GO:0009611	response to wounding
GO:0030182	neuron differentiation
GO:0030855	epithelial cell differentiation
GO:0030903	notochord development
GO:0042476	odontogenesis
GO:0043065	positive regulation of apoptotic process
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045662	negative regulation of myoblast differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051726	regulation of cell cycle