InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: E2f2

Summary

InnateDB Protein

IDBP-197709.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2f2

Protein Name

E2F transcription factor 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050047

InnateDB Gene

IDBG-197705 (E2f2)

Protein Structure

UniProt Annotation

Function

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001047	core promoter binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0051726	regulation of cell cycle
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:1990086	lens fiber cell apoptotic process