InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hyal1

Summary

InnateDB Protein

IDBP-197766.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hyal1

Protein Name

hyaluronoglucosaminidase 1

Synonyms

Hya1; Hyal-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000010195

InnateDB Gene

IDBG-197764 (Hyal1)

Protein Structure

UniProt Annotation

Function

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. {ECO:0000269PubMed:11960552}.

Subcellular Localization

Secreted {ECO:0000250}. Lysosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in liver, kidney, lung and skin. {ECO:0000269PubMed:11929860, ECO:0000269PubMed:9503017}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004415	hyalurononglucosaminidase activity
GO:0008134	transcription factor binding
GO:0050501	hyaluronan synthase activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0005975	carbohydrate metabolic process
GO:0006954	inflammatory response
GO:0009615	response to virus
GO:0010634	positive regulation of epithelial cell migration
GO:0030212	hyaluronan metabolic process
GO:0030213	hyaluronan biosynthetic process
GO:0030214	hyaluronan catabolic process
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0036120	cellular response to platelet-derived growth factor stimulus
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0045927	positive regulation of growth
GO:0046677	response to antibiotic
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051216	cartilage development
GO:0060272	embryonic skeletal joint morphogenesis
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071467	cellular response to pH
GO:0071493	cellular response to UV-B
GO:1900106	positive regulation of hyaluranon cable assembly

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0031410	cytoplasmic vesicle
GO:0036117	hyaluranon cable
GO:0070062	extracellular vesicular exosome