InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rasgrp1

Summary

InnateDB Protein

IDBP-197784.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rasgrp1

Protein Name

RAS guanyl releasing protein 1

Synonyms

Rasgrp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099593

InnateDB Gene

IDBG-197782 (Rasgrp1)

Protein Structure

UniProt Annotation

Function

Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation. Proto-oncogene which promotes T-cell lymphomagenesis when its expression is deregulated. {ECO:0000269PubMed:11017103, ECO:0000269PubMed:12433368, ECO:0000269PubMed:12538669, ECO:0000269PubMed:12845332, ECO:0000269PubMed:12932358, ECO:0000269PubMed:14532295, ECO:0000269PubMed:14970203, ECO:0000269PubMed:15829980, ECO:0000269PubMed:16301621, ECO:0000269PubMed:16849453, ECO:0000269PubMed:17190838, ECO:0000269PubMed:17210708, ECO:0000269PubMed:9819387}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Found both in the cytosol and associated with membranes. Relocalization to the cell membrane upon activation is F-actin-dependent (By similarity). Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in spleen and thymus. Expressed by mature thymocytes and to a lower extent by bone marrow-derived mast cells (at protein level). Detected in B-cells and keratinocytes (at protein level). {ECO:0000269PubMed:11017103, ECO:0000269PubMed:12433368, ECO:0000269PubMed:14532295, ECO:0000269PubMed:14970203, ECO:0000269PubMed:17190838, ECO:0000269PubMed:9819387}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding

Biological Process

GO:0001816	cytokine production
GO:0002437	inflammatory response to antigenic stimulus
GO:0007264	small GTPase mediated signal transduction
GO:0014066	regulation of phosphatidylinositol 3-kinase signaling
GO:0030154	cell differentiation
GO:0032252	secretory granule localization
GO:0032856	activation of Ras GTPase activity
GO:0032862	activation of Rho GTPase activity
GO:0035556	intracellular signal transduction
GO:0043303	mast cell degranulation
GO:0047496	vesicle transport along microtubule
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0042629	mast cell granule

Protein Structure and Domains

PDB ID

MGI:1314635

InterPro

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR002048 EF-hand domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR020454 Diacylglycerol/phorbol-ester binding
IPR023578 Ras guanine nucleotide exchange factor, domain

PFAM

PF00618
PF00617
PF00036
PF13202
PF13405
PF00130

PRINTS

PR00008

PIRSF

SMART

SM00229
SM00147
SM00054
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt