InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gsg2

Summary

InnateDB Protein

IDBP-197827.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gsg2

Protein Name

germ cell-specific gene 2

Synonyms

Haspin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000055806

InnateDB Gene

IDBG-197825 (Gsg2)

Protein Structure

UniProt Annotation

Function

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269PubMed:10358056, ECO:0000269PubMed:15681610}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10358056}. Chromosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in germ cells within the testis of adults and of embryos from day 24 onwards. Also present in adult thymus and weakly expressed in spleen, lung and whole embryo. {ECO:0000269PubMed:10358056, ECO:0000269PubMed:11311556, ECO:0000269PubMed:7957958}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0072354	histone kinase activity (H3-T3 specific)

Biological Process

GO:0006468	protein phosphorylation
GO:0007064	mitotic sister chromatid cohesion
GO:0035556	intracellular signal transduction
GO:0071459	protein localization to chromosome, centromeric region
GO:0090231	regulation of spindle checkpoint
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle
GO:2000751	histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0031965	nuclear membrane

Protein Structure and Domains

PDB ID

MGI:1194498

InterPro

IPR000719 Protein kinase domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR024604 Domain of unknown function DUF3635

PFAM

PF00069
PF12330

PRINTS

PIRSF

SMART

SM00220

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z0R0