Version 5.4
Mus musculus Protein: Ivns1abp
Summary
InnateDB Protein IDBP-197857.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ivns1abp
Protein Name influenza virus NS1A binding protein
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000023918
InnateDB Gene IDBG-197855 (Ivns1abp)
Protein Structure
UniProt Annotation
Function Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Plays a role in protecting the heart from doxorubicin-induced cardiomyopathy. Activates Erk signaling pathway when overexpressed in cultured cell lines. {ECO:0000269PubMed:11418182, ECO:0000269PubMed:12213805, ECO:0000269PubMed:15684717, ECO:0000269PubMed:16317045, ECO:0000269PubMed:16952015}.
Subcellular Localization Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with actin filaments.Isoform 2: Nucleus.
Disease Associations
Tissue Specificity Ubiquitous expression. In the heart, the highest expression is detected in the ventricles and the lowest in the atria. Expressed in dendrites and spines in neurons. {ECO:0000269PubMed:12213805, ECO:0000269PubMed:15684717, ECO:0000269PubMed:16317045}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID MGI:2152389
InterPro IPR000210 BTB/POZ-like
IPR006652 Kelch repeat type 1
IPR011333 BTB/POZ fold
IPR011498 Kelch repeat type 2
IPR011705 BTB/Kelch-associated
IPR013069 BTB/POZ
IPR017096 Kelch-like protein, gigaxonin type
PFAM PF01344
PF07646
PF07707
PF00651
PRINTS
PIRSF PIRSF037037
SMART SM00225
SM00612
SM00875
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q920Q8
PhosphoSite PhosphoSite-Q920Q8
TrEMBL Q06BK5
UniProt Splice Variant
Entrez Gene 117198
UniGene Mm.457400
RefSeq NP_473443
MGI ID
MGI Symbol Ivns1abp
OMIM
CCDS CCDS15359
HPRD
IMGT
EMBL AB055737 AB055738 AK007291 AK129229 AK144835 AK145071 AK146001 AK146329 AK146494 AK146645 AK159254 BC004092 BC040250 DQ914522 DQ914523
GenPept AAH04092 AAH40250 ABI84241 ABI84242 BAB24936 BAB69058 BAB69059 BAC98039 BAE26089 BAE26221 BAE26822 BAE27084 BAE27212 BAE27326 BAE34935

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca