Version 5.4
| Mus musculus Protein: Tcea3 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-197862.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Tcea3 | ||||||||
| Protein Name | transcription elongation factor A (SII), 3 | ||||||||
| Synonyms | S-II; SII-K1; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000099592 | ||||||||
| InnateDB Gene | IDBG-197860 (Tcea3) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. | ||||||||
| Subcellular Localization | Nucleus {ECO:0000305}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Liver, kidney and heart. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1196908 | ||||||||
| InterPro |
IPR001222
Zinc finger, TFIIS-type IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type IPR003618 Transcription elongation factor S-II, central domain IPR006289 Transcription elongation factor, TFIIS IPR016492 Transcription elongation factor, TFIIS-related IPR017890 Transcription elongation factor S-IIM IPR017923 Transcription factor IIS, N-terminal |
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| PFAM |
PF01096
PF07500 PF08711 |
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| PRINTS | |||||||||
| PIRSF |
PIRSF006704
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| SMART |
SM00440
SM00509 SM00510 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P23881 | ||||||||
| PhosphoSite | PhosphoSite-P23881 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 21401 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_035672 | ||||||||
| MGI ID | 1WJT | ||||||||
| MGI Symbol | Tcea3 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS18803 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AJ223472 AK002319 AK007437 AK019024 AL935264 BC010807 D00926 | ||||||||
| GenPept | AAH10807 BAA28177 BAB22010 BAB25037 BAB31514 CAA11392 CAM13835 | ||||||||