InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itpr2

Summary

InnateDB Protein

IDBP-197948.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itpr2

Protein Name

inositol 1,4,5-triphosphate receptor 2

Synonyms

AI649341; InsP3R-2; InsP3R-5; insP3R2; Ip3r2; Itpr5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049584

InnateDB Gene

IDBG-197946 (Itpr2)

Protein Structure

UniProt Annotation

Function

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.Isoform 3 has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15632133}; Multi-pass membrane protein {ECO:0000269PubMed:15632133}.

Disease Associations

Tissue Specificity

Isoforms 1 and 3 are widely expressed. Isoform 2 is found in skeletal muscle and heart. {ECO:0000269PubMed:15632133}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0015278	calcium-release channel activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0001666	response to hypoxia
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0048016	inositol phosphate-mediated signaling
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0071320	cellular response to cAMP
GO:0071361	cellular response to ethanol

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0033017	sarcoplasmic reticulum membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:99418

InterPro

IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR000699 RIH (RyR and IP3R Homology) domain
IPR005821 Ion transport domain
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016024 Armadillo-type fold
IPR016093 MIR motif

PFAM

PF01365
PF00520
PF08454
PF08709
PF02815

PRINTS

PR00779

PIRSF

SMART

SM00472

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt