InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tax1bp3

Summary

InnateDB Protein

IDBP-197956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tax1bp3

Protein Name

Tax1 (human T-cell leukemia virus type I) binding protein 3

Synonyms

1300011C24Rik; TIP-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047410

InnateDB Gene

IDBG-197954 (Tax1bp3)

Protein Structure

UniProt Annotation

Function

May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12874278}. Nucleus {ECO:0000269PubMed:12874278}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to the cell membrane by interaction with membrane proteins. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0007266	Rho protein signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0016055	Wnt signaling pathway
GO:0030111	regulation of Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0032864	activation of Cdc42 GTPase activity
GO:2000009	negative regulation of protein localization to cell surface