InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aspa

Summary

InnateDB Protein

IDBP-198141.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aspa

Protein Name

aspartoacylase

Synonyms

Acy-2; Acy2; nur7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021119

InnateDB Gene

IDBG-198139 (Aspa)

Protein Structure

UniProt Annotation

Function

Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004046	aminoacylase activity
GO:0016788	hydrolase activity, acting on ester bonds
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0019807	aspartoacylase activity
GO:0046872	metal ion binding

Biological Process

GO:0006083	acetate metabolic process
GO:0008152	metabolic process
GO:0022010	central nervous system myelination
GO:0048714	positive regulation of oligodendrocyte differentiation