InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bub1b

Summary

InnateDB Protein

IDBP-198181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bub1b

Protein Name

budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)

Synonyms

AU045529; BUBR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037126

InnateDB Gene

IDBG-198179 (Bub1b)

Protein Structure

UniProt Annotation

Function

Essential component of the mitotic checkpoint. Required for normal mitosis progression and tumor suppression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. Essential for tumor suppression. May play a role in regulating aging and fertility (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:12925705, ECO:0000269PubMed:17925231}. Note=Cytoplasmic in interphase cells (By similarity). Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and CASC5 (By similarity). {ECO:0000250}.

Disease Associations

Note=Defects in Bub1b are involved in the development of lung and intestinal adenocarcinomas after exposure to a carcinogen.

Tissue Specificity

Highly expressed in thymus followed by spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007091	metaphase/anaphase transition of mitotic cell cycle
GO:0034501	protein localization to kinetochore
GO:0071459	protein localization to chromosome, centromeric region

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000778	condensed nuclear chromosome kinetochore
GO:0000940	condensed chromosome outer kinetochore
GO:0005737	cytoplasm
GO:0048471	perinuclear region of cytoplasm