Version 5.4
| Mus musculus Protein: C1qb | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-198226.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | C1qb | ||||||||
| Protein Name | complement component 1, q subcomponent, beta polypeptide | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000040246 | ||||||||
| InnateDB Gene | IDBG-198224 (C1qb) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. | ||||||||
| Subcellular Localization | Secreted. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Highest expression in thioglycolate-activated peritoneal macrophages. Also found in spleen, thymus and heart. Very weak expression liver, kidney, lung and intestine. {ECO:0000269PubMed:2591537}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:88224 | ||||||||
| InterPro |
IPR001073
Complement C1q protein IPR008160 Collagen triple helix repeat IPR008983 Tumour necrosis factor-like domain |
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| PFAM |
PF00386
PF01391 |
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| PRINTS |
PR00007
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| PIRSF | |||||||||
| SMART |
SM00110
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P14106 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 12260 | ||||||||
| UniGene | Mm.416830 | ||||||||
| RefSeq | NP_033907 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | C1qb | ||||||||
| OMIM | |||||||||
| CCDS | CCDS18810 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK152764 AL627214 BC067001 M22531 M36293 X16874 X92959 | ||||||||
| GenPept | AAA37283 AAA37335 AAH67001 BAE31477 CAA34757 CAA63534 CAM46144 | ||||||||