InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: C1qc

Summary

InnateDB Protein

IDBP-198258.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C1qc

Protein Name

complement component 1, q subcomponent, C chain

Synonyms

AI385742; C1qg; Ciqc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036747

InnateDB Gene

IDBG-198256 (C1qc)

Protein Structure

UniProt Annotation

Function

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0006958	complement activation, classical pathway
GO:0030853	negative regulation of granulocyte differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045650	negative regulation of macrophage differentiation

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0005615	extracellular space
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle

Protein Structure and Domains

PDB ID

MGI:88225

InterPro

IPR001073 Complement C1q protein
IPR006052 Tumour necrosis factor domain
IPR008160 Collagen triple helix repeat
IPR008983 Tumour necrosis factor-like domain

PFAM

PF00386
PF00229
PF01391

PRINTS

PR00007

PIRSF

SMART

SM00110
SM00207

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt