InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFNAR2

Summary

InnateDB Protein

IDBP-1983.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFNAR2

Protein Name

interferon (alpha, beta and omega) receptor 2

Synonyms

IFN-alpha-REC; IFN-R; IFNABR; IFNARB;

Species

Homo sapiens

Ensembl Protein

ENSP00000343957

InnateDB Gene

IDBG-1973 (IFNAR2)

Protein Structure

UniProt Annotation

Function

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. {ECO:0000269PubMed:11682488, ECO:0000269PubMed:12105218, ECO:0000269PubMed:7665574, ECO:0000269PubMed:7759950, ECO:0000269PubMed:8181059}.

Subcellular Localization

Isoform 1: Membrane; Single-pass type I membrane protein.Isoform 2: Membrane; Single-pass type I membrane protein.Isoform 3: Secreted.

Disease Associations

Tissue Specificity

Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. {ECO:0000269PubMed:7588638, ECO:0000269PubMed:7759950, ECO:0000269PubMed:8181059}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	32 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004905	type I interferon receptor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019962	type I interferon binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007166	cell surface receptor signaling pathway
GO:0007259	JAK-STAT cascade
GO:0008283	cell proliferation
GO:0009615	response to virus
GO:0019221	cytokine-mediated signaling pathway
GO:0035455	response to interferon-alpha
GO:0045087	innate immune response (InnateDB)
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway