InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLAT

Summary

InnateDB Protein

IDBP-19831.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLAT

Protein Name

plasminogen activator, tissue

Synonyms

T-PA; TPA;

Species

Homo sapiens

Ensembl Protein

ENSP00000220809

InnateDB Gene

IDBG-19829 (PLAT)

Protein Structure

UniProt Annotation

Function

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.

Tissue Specificity

Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0014909	smooth muscle cell migration
GO:0031639	plasminogen activation
GO:0035249	synaptic transmission, glutamatergic
GO:0042060	wound healing
GO:0042730	fibrinolysis
GO:0043434	response to peptide hormone
GO:0045861	negative regulation of proteolysis
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048167	regulation of synaptic plasticity
GO:0051591	response to cAMP
GO:0060279	positive regulation of ovulation
GO:0071549	cellular response to dexamethasone stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0030141	secretory granule
GO:0045177	apical part of cell
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000001 Kringle
IPR000083 Fibronectin, type I
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR013806 Kringle-like fold

PFAM

PF00051
PF00039
PF00008
PF00089

PRINTS

PR00722

PIRSF

SMART

SM00130
SM00058
SM00181
SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt