InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stk38l

Summary

InnateDB Protein

IDBP-198431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stk38l

Protein Name

serine/threonine kinase 38 like

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001675

InnateDB Gene

IDBG-198429 (Stk38l)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of structural processes in differentiating and mature neuronal cells. {ECO:0000269PubMed:15308672, ECO:0000269PubMed:21730291}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15308672}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:15308672}. Membrane {ECO:0000269PubMed:15308672}. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.

Disease Associations

Tissue Specificity

Highly expressed in the large and small intestine, stomach and testis. High levels also present in the brain, in particular the neurocortex, basal forebrain, hippocampus, the amygdala, cerebellum and brainstem. {ECO:0000269PubMed:15037617, ECO:0000269PubMed:15308672}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003779	actin binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0035556	intracellular signal transduction
GO:0051128	regulation of cellular component organization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton

Protein Structure and Domains

PDB ID

MGI:1922250

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00433

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt