Version 5.4
Homo sapiens Protein: THSD4
Summary
InnateDB Protein IDBP-19852.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THSD4
Protein Name thrombospondin, type I, domain containing 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000261862
InnateDB Gene IDBG-19850 (THSD4)
Protein Structure
UniProt Annotation
Function Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR010294 ADAM-TS Spacer 1
PFAM PF05986
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZMP0
PhosphoSite PhosphoSite-Q6ZMP0
TrEMBL
UniProt Splice Variant
Entrez Gene 79875
UniGene Hs.603913
RefSeq
HUGO HGNC:25835
OMIM 614476
CCDS
HPRD 07835
IMGT
EMBL AC015711 AC026636 AC064799 AC068181 AC104938 AC104943 AC105132 AC108861 AK023772 AK131551 AK299056 AY358143 BC140868 BX641106
GenPept AAI40869 AAQ88510 BAB14673 BAD18685 BAG61125 CAE46049

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca