InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: P2rx4

Summary

InnateDB Protein

IDBP-198529.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2rx4

Protein Name

purinergic receptor P2X, ligand-gated ion channel 4

Synonyms

AI504491; AW555605; D5Ertd444e; P2X4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031429

InnateDB Gene

IDBG-198527 (P2rx4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005102	receptor binding
GO:0005216	ion channel activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008144	drug binding
GO:0008270	zinc ion binding
GO:0045296	cadherin binding

Biological Process

GO:0002028	regulation of sodium ion transport
GO:0006809	nitric oxide biosynthetic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0007165	signal transduction
GO:0008217	regulation of blood pressure
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0019228	neuronal action potential
GO:0019233	sensory perception of pain
GO:0033198	response to ATP
GO:0034220	ion transmembrane transport
GO:0034405	response to fluid shear stress
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0042311	vasodilation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0051260	protein homooligomerization
GO:0051899	membrane depolarization
GO:0055117	regulation of cardiac muscle contraction
GO:0055119	relaxation of cardiac muscle
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0071318	cellular response to ATP
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043197	dendritic spine
GO:0045177	apical part of cell
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome