Version 5.4
Mus musculus Protein: Arpc5
Summary
InnateDB Protein IDBP-198578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arpc5
Protein Name actin related protein 2/3 complex, subunit 5
Synonyms 5830443F10Rik; p16-Arc;
Species Mus musculus
Ensembl Protein ENSMUSP00000076933
InnateDB Gene IDBG-198576 (Arpc5)
Protein Structure
UniProt Annotation
Function Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0030833 regulation of actin filament polymerization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0030027 lamellipodium
Protein Structure and Domains
PDB ID MGI:1915021
InterPro IPR006789 ARP2/3 complex, 16kDa subunit (p16-Arc)
PFAM PF04699
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CPW4
PhosphoSite PhosphoSite-Q9CPW4
TrEMBL Q3TK56
UniProt Splice Variant
Entrez Gene 67771
UniGene Mm.405746
RefSeq NP_080645
MGI ID
MGI Symbol Arpc5
OMIM
CCDS CCDS35739
HPRD
IMGT
EMBL AK008097 AK011348 AK011911 AK017669 AK019149 AK087427 AK149756 AK151654 AK151656 AK152281 AK153262 AK159407 AK159438 AK159738 AK166284 AK166335 AK166725 AK167144 AK167916 AK168264 AK168986 BC060143
GenPept AAH60143 BAB25457 BAB27558 BAB27911 BAB30864 BAB31570 BAC39870 BAE29064 BAE30583 BAE30585 BAE31095 BAE31852 BAE35058 BAE35084 BAE35332 BAE38681 BAE38714 BAE38972 BAE39289 BAE39923 BAE40212 BAE40786

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca