Version 5.4
| Homo sapiens Protein: THSD4 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-19858.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | THSD4 | ||||||||
| Protein Name | thrombospondin, type I, domain containing 4 | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000347484 | ||||||||
| InnateDB Gene | IDBG-19850 (THSD4) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted, extracellular space, extracellular matrix {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000884
Thrombospondin, type 1 repeat IPR010294 ADAM-TS Spacer 1 IPR010909 PLAC |
||||||||
| PFAM |
PF00090
PF05986 PF08686 |
||||||||
| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00209
|
||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q6ZMP0 | ||||||||
| PhosphoSite | PhosphoSite-Q6ZMP0 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 79875 | ||||||||
| UniGene | Hs.603913 | ||||||||
| RefSeq | NP_079093 | ||||||||
| HUGO | HGNC:25835 | ||||||||
| OMIM | 614476 | ||||||||
| CCDS | CCDS10238 | ||||||||
| HPRD | 07835 | ||||||||
| IMGT | |||||||||
| EMBL | AC015711 AC026636 AC064799 AC068181 AC104938 AC104943 AC105132 AC108861 AK023772 AK131551 AK299056 AY358143 BC140868 BX641106 | ||||||||
| GenPept | AAI40869 AAQ88510 BAB14673 BAD18685 BAG61125 CAE46049 | ||||||||