InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ncf2

Summary

InnateDB Protein

IDBP-198620.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ncf2

Protein Name

neutrophil cytosolic factor 2

Synonyms

Ncf-2; NOXA2; p67phox;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027754

InnateDB Gene

IDBG-198618 (Ncf2)

Protein Structure

UniProt Annotation

Function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). {ECO:0000250UniProtKB:P19878}.

Subcellular Localization

Cytoplasm {ECO:0000250UniProtKB:P19878}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0006742	NADP catabolic process
GO:0006801	superoxide metabolic process
GO:0007568	aging
GO:0009749	response to glucose
GO:0014823	response to activity
GO:0032496	response to lipopolysaccharide
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0034616	response to laminar fluid shear stress
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0043525	positive regulation of neuron apoptotic process
GO:0045777	positive regulation of blood pressure
GO:0055093	response to hyperoxia
GO:0055114	oxidation-reduction process

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:97284

InterPro

IPR000270 Phox/Bem1p
IPR001440 Tetratricopeptide TPR1
IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM