InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddah1

Summary

InnateDB Protein

IDBP-198717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddah1

Protein Name

dimethylarginine dimethylaminohydrolase 1

Synonyms

2410006N07Rik; 2510015N06Rik; AI987801; AW050362;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029845

InnateDB Gene

IDBG-198715 (Ddah1)

Protein Structure

UniProt Annotation

Function

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269PubMed:17273169}.

Subcellular Localization

Disease Associations

Tissue Specificity

Detected in skeletal muscle, lung, heart and brain (at protein level). Detected in liver, kidney and lung. {ECO:0000269PubMed:17273169}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008270	zinc ion binding
GO:0016403	dimethylargininase activity
GO:0016597	amino acid binding
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Biological Process

GO:0000052	citrulline metabolic process
GO:0003073	regulation of systemic arterial blood pressure
GO:0006525	arginine metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0017014	protein nitrosylation
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045766	positive regulation of angiogenesis