InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Anapc5

Summary

InnateDB Protein

IDBP-198738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Anapc5

Protein Name

anaphase-promoting complex subunit 5

Synonyms

2510006G12Rik; AA408751; AA536819; AA986414; Anpc5; APC5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083393

InnateDB Gene

IDBG-198736 (Anapc5)

Protein Structure

UniProt Annotation

Function

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019903	protein phosphatase binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0070979	protein K11-linked ubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005680	anaphase-promoting complex

Protein Structure and Domains

PDB ID

MGI:1929722

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-Q8BTZ4

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AB041593 AK012579 AK013978 AK031432 AK049719 AK088327 AK148679 AK159713 AK159916 AK168814 AK169196 BC010339 BC046566 BC046804

GenPept

AAH10339 AAH46566 AAH46804 BAA95076 BAB28331 BAB29097 BAC27401 BAC33891 BAC40284 BAE28639 BAE35309 BAE35479 BAE40641 BAE40972

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca