Version 5.4
Mus musculus Protein: Chst14
Summary
InnateDB Protein IDBP-198743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Chst14
Protein Name carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
Synonyms 2600016L03Rik; D4ST-1; D4st1;
Species Mus musculus
Ensembl Protein ENSMUSP00000099579
InnateDB Gene IDBG-198741 (Chst14)
Protein Structure
UniProt Annotation
Function Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. GlcUA to IdoUA. Appears to have an important role in the formation of the cerbellar neural network during postnatal brain development. {ECO:0000269PubMed:16702220}.
Subcellular Localization Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity
GO:0005515 protein binding
GO:0008146 sulfotransferase activity
Biological Process
GO:0016051 carbohydrate biosynthetic process
GO:0050655 dermatan sulfate proteoglycan metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1919386
InterPro IPR005331 Sulfotransferase
PFAM PF03567
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80V53
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 72136
UniGene Mm.490292
RefSeq NP_082393
MGI ID
MGI Symbol Chst14
OMIM
CCDS CCDS16587
HPRD
IMGT
EMBL AK011230 AK154636 AK159357 AK171614 AL845164 BC026886 BC043700 BC085479
GenPept AAH26886 AAH43700 AAH85479 BAB27480 BAE32731 BAE35015 BAE42565 CAM19755

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca