Mus musculus Protein: Far2 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||
InnateDB Protein | IDBP-198892.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Far2 | ||||||||||||||
Protein Name | fatty acyl CoA reductase 2 | ||||||||||||||
Synonyms | |||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000032443 | ||||||||||||||
InnateDB Gene | IDBG-198890 (Far2) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. The preferred substrates are C16, C18, C18:1 and C18:2 but low activity can be observed with C10-C14 substrates. {ECO:0000269PubMed:15220348}. | ||||||||||||||
Subcellular Localization | Peroxisome membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Peroxisome in cells expressing low levels of the protein. Peroxisome and endoplasmic reticulum in cells expressing high levels of the protein (Potential). {ECO:0000305}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | Highly expressed in the meibomian glands of the eyelid and the sebaceous glands of the skin. Expressed in the brain where large quantities of ether lipids are synthesized. {ECO:0000269PubMed:15220348}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
||||||||||||||
Gene Ontology | |||||||||||||||
Molecular Function |
|
||||||||||||||
Biological Process |
|
||||||||||||||
Cellular Component |
|
||||||||||||||
Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:2687035 | ||||||||||||||
InterPro |
IPR001509
NAD-dependent epimerase/dehydratase IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase IPR003869 Polysaccharide biosynthesis protein, CapD-like domain IPR013120 Male sterility, NAD-binding IPR026055 Fatty acyl-CoA reductase |
||||||||||||||
PFAM |
PF01370
PF01073 PF02719 PF07993 PF03015 |
||||||||||||||
PRINTS | |||||||||||||||
PIRSF | |||||||||||||||
SMART | |||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | Q7TNT2 | ||||||||||||||
PhosphoSite | PhosphoSite-Q7TNT2 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 330450 | ||||||||||||||
UniGene | Mm.475174 | ||||||||||||||
RefSeq | XP_006507132 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Far2 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AK038584 AK043388 AK043589 AK161201 BC055759 CU207318 | ||||||||||||||
GenPept | AAH55759 BAC30056 BAC31532 BAC31590 BAE36237 CAQ51877 | ||||||||||||||