Version 5.4
Mus musculus Protein: Tcf25
Summary
InnateDB Protein IDBP-198948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tcf25
Protein Name transcription factor 25 (basic helix-loop-helix)
Synonyms 1100001J13Rik; 1810041K11Rik; D8Ertd325e; mKIAA1049; Nulp1;
Species Mus musculus
Ensembl Protein ENSMUSP00000056485
InnateDB Gene IDBG-198946 (Tcf25)
Protein Structure
UniProt Annotation
Function May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:12107429, ECO:0000269PubMed:18068114}. Note=Some staining in the cytosol; cytosolic localization is reduced in staurosporine-induced cell death.
Disease Associations
Tissue Specificity Broadly expressed in the embryo during the early stages of organogenesis with highest levels in dorsal root ganglia and little or no expression in liver and skin. {ECO:0000269PubMed:12107429}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1914105
InterPro IPR006994 Transcription factor 25
PFAM PF04910
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R3L2
PhosphoSite PhosphoSite-Q8R3L2
TrEMBL
UniProt Splice Variant
Entrez Gene 66855
UniGene Mm.401513
RefSeq NP_001032967
MGI ID
MGI Symbol Tcf25
OMIM
CCDS CCDS22755
HPRD
IMGT
EMBL AK013754 AK045397 AK076151 AK088360 AK089964 AK148082 AK150232 AK150918 AK150942 AK151143 AK152178 AK152494 AK161627 AK167837 AK168167 BC025071 BC046768 U94988
GenPept AAG27133 AAH25071 AAH46768 BAB28983 BAC32344 BAC36220 BAC40301 BAC41018 BAE28334 BAE29397 BAE29956 BAE29977 BAE30150 BAE31009 BAE31265 BAE36500 BAE39858 BAE40128

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca