InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ip6k1

Summary

InnateDB Protein

IDBP-198953.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ip6k1

Protein Name

inositol hexaphosphate kinase 1

Synonyms

1200016D08Rik; AU022776; Ihpk1; InsP6; InsP6k1; Itpk6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035214

InnateDB Gene

IDBG-198951 (Ip6k1)

Protein Structure

UniProt Annotation

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. {ECO:0000269PubMed:10574768}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain and testis. Detected at much lower levels in heart, kidney, liver, lung and spleen. {ECO:0000269PubMed:10574768}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000832	inositol hexakisphosphate 5-kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity
GO:0052723	inositol hexakisphosphate 1-kinase activity
GO:0052724	inositol hexakisphosphate 3-kinase activity

Biological Process

GO:0006020	inositol metabolic process
GO:0032958	inositol phosphate biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0046854	phosphatidylinositol phosphorylation