InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mnt

Summary

InnateDB Protein

IDBP-199025.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mnt

Protein Name

max binding protein

Synonyms

bHLHd3; Rox;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000291

InnateDB Gene

IDBG-199023 (Mnt)

Protein Structure

UniProt Annotation

Function

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007569	cell aging
GO:0051726	regulation of cell cycle
GO:2001234	negative regulation of apoptotic signaling pathway