InnateDB Protein
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IDBP-199109.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ppp1r14d
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Protein Name
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protein phosphatase 1, regulatory (inhibitor) subunit 14D
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Synonyms
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2010107K19Rik; GBPI-1; Ppp1r14;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000075453
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InnateDB Gene
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IDBG-199107 (Ppp1r14d)
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Protein Structure
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Function |
Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is detected in intestine, kidney, lung, spleen, stomach and brain. Isoform 2 is detected in testis. {ECO:0000269PubMed:12974676}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0004864
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protein phosphatase inhibitor activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1919362
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InterPro |
IPR008025
PKC-activated phosphatase-1 inhibitor
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PFAM |
PF05361
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7TT52
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PhosphoSite |
PhosphoSite-Q7TT52
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
72112
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UniGene |
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RefSeq |
NP_082380
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MGI ID |
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MGI Symbol |
Ppp1r14d
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OMIM |
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CCDS |
CCDS16596
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HPRD |
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IMGT |
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EMBL |
AF408400
AK008348
AL929318
AY179331
BC024547
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GenPept |
AAH24547
AAK97532
AAO47399
BAB25620
CAM25336
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