InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ctbs

Summary

InnateDB Protein

IDBP-199247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ctbs

Protein Name

chitobiase, di-N-acetyl-

Synonyms

2210401K11Rik; CTB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059167

InnateDB Gene

IDBG-199245 (Ctbs)

Protein Structure

UniProt Annotation

Function

Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568	chitinase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006032	chitin catabolic process
GO:0009313	oligosaccharide catabolic process

Cellular Component

GO:0005764

lysosome

Protein Structure and Domains

PDB ID

MGI:1921495

InterPro

IPR001223 Glycoside hydrolase, family 18, catalytic domain
IPR011583 Chitinase II
IPR017853 Glycoside hydrolase, superfamily

PFAM

PF00704

PRINTS

PIRSF

SMART

SM00636

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R242

PhosphoSite

PhosphoSite-

TrEMBL

Q102J0

UniProt Splice Variant

Entrez Gene

74245

UniGene

RefSeq

XP_006502214

MGI ID

MGI Symbol

Ctbs

OMIM

CCDS

HPRD

IMGT

EMBL

AC124987 AK008791 BC022594 CH466532 DQ100377 DQ100378 DQ100379 DQ100380 DQ100381 DQ100382 DQ100383 DQ100384

GenPept

AAH22594 ABC33736 ABC33737 BAB25896 EDL11974