Mus musculus Protein: Apeh
Summary
InnateDB Protein IDBP-199323.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Apeh
Protein Name acylpeptide hydrolase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000080058
InnateDB Gene IDBG-199321 (Apeh)
Protein Structure
UniProt Annotation
Function This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0008242 omega peptidase activity
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006508 proteolysis
GO:0050435 beta-amyloid metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:88041
InterPro IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR002925 Dienelactone hydrolase
IPR029058 Alpha/Beta hydrolase fold
PFAM PF00326
PF01738
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R146
PhosphoSite PhosphoSite-Q8R146
TrEMBL
UniProt Splice Variant
Entrez Gene 235606
UniGene
RefSeq NP_666338
MGI ID
MGI Symbol Apeh
OMIM
CCDS CCDS52923
HPRD
IMGT
EMBL AC137678 BC025494 BC026594 BC034199 CH466560
GenPept AAH25494 AAH26594 AAH34199 EDL21266