InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Afg3l1

Summary

InnateDB Protein

IDBP-199410.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Afg3l1

Protein Name

AFG3(ATPase family gene 3)-like 1 (yeast)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001520

InnateDB Gene

IDBG-199408 (Afg3l1)

Protein Structure

UniProt Annotation

Function

Putative ATP-dependent protease.

Subcellular Localization

Mitochondrion membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004222	metalloendopeptidase activity
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006508	proteolysis
GO:0007005	mitochondrion organization
GO:0008053	mitochondrial fusion
GO:0034982	mitochondrial protein processing
GO:0042407	cristae formation

Cellular Component

GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

MGI:1928277

InterPro

IPR000642 Peptidase M41
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR005936 Peptidase, FtsH
IPR011546 Peptidase M41, FtsH extracellular
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01434
PF00004
PF07724
PF13304
PF06480

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q920A7