InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Smg6

Summary

InnateDB Protein

IDBP-199516.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Smg6

Protein Name

Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)

Synonyms

AI317223; AU041178;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043555

InnateDB Gene

IDBG-199514 (Smg6)

Protein Structure

UniProt Annotation

Function

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'- (GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER) (By similarity). {ECO:0000250}.Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Chromosome, telomere {ECO:0000305}. Cytoplasm, cytosol {ECO:0000250}. Note=Particularly enriched in the nucleolus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004521	endoribonuclease activity
GO:0005515	protein binding
GO:0042162	telomeric DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000723	telomere maintenance
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic