InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cyp1b1

Summary

InnateDB Protein

IDBP-199557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cyp1b1

Protein Name

cytochrome P450, family 1, subfamily b, polypeptide 1

Synonyms

CP1B; P4501b1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024894

InnateDB Gene

IDBG-199555 (Cyp1b1)

Protein Structure

UniProt Annotation

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression. {ECO:0000269PubMed:15258110, ECO:0000269PubMed:19005183, ECO:0000269PubMed:20032512, ECO:0000269PubMed:23568032, ECO:0000269PubMed:23821647, ECO:0000269PubMed:23979599}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:23692925}; Peripheral membrane protein {ECO:0000269PubMed:23692925}. Microsome membrane {ECO:0000269PubMed:23692925}; Peripheral membrane protein {ECO:0000269PubMed:23692925}. Mitochondrion {ECO:0000269PubMed:23692925}.

Disease Associations

Tissue Specificity

Constitutively expressed in retinal, heart and kidney pericytes cells. {ECO:0000269PubMed:23568032}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037	heme binding
GO:0070330	aromatase activity

Biological Process

GO:0001525	angiogenesis
GO:0002930	trabecular meshwork development
GO:0006725	cellular aromatic compound metabolic process
GO:0006805	xenobiotic metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0007155	cell adhesion
GO:0008202	steroid metabolic process
GO:0008210	estrogen metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009404	toxin metabolic process
GO:0009636	response to toxic substance
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0019369	arachidonic acid metabolic process
GO:0030199	collagen fibril organization
GO:0030336	negative regulation of cell migration
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0033629	negative regulation of cell adhesion mediated by integrin
GO:0042572	retinol metabolic process
GO:0042574	retinal metabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043542	endothelial cell migration
GO:0045766	positive regulation of angiogenesis
GO:0046427	positive regulation of JAK-STAT cascade
GO:0046466	membrane lipid catabolic process
GO:0048514	blood vessel morphogenesis
GO:0055114	oxidation-reduction process
GO:0061298	retina vasculature development in camera-type eye
GO:0061304	retinal blood vessel morphogenesis
GO:0070301	cellular response to hydrogen peroxide
GO:0071407	cellular response to organic cyclic compound
GO:0071603	endothelial cell-cell adhesion
GO:1901313	positive regulation of gene expression involved in extracellular matrix organization
GO:2000377	regulation of reactive oxygen species metabolic process