InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Neurod4

Summary

InnateDB Protein

IDBP-199577.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Neurod4

Protein Name

neurogenic differentiation 4

Synonyms

AI846749; ATH-3; Atoh3; bHLHa4; MATH-3; Math3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051379

InnateDB Gene

IDBG-199575 (Neurod4)

Protein Structure

UniProt Annotation

Function

Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina. {ECO:0000269PubMed:11861467}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Expressed in retinal interneurons amacrine cells (at protein level). Expressed in neurons of ventricular zone of the retina at postnatal day 1 (P1). Expressed transiently in amacrine and horizontal cells of the inner nuclear layer (INL) of the retina at P7 until P14. {ECO:0000269PubMed:11861467, ECO:0000269PubMed:9029157, ECO:0000269PubMed:9497361}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0001764	neuron migration
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0007405	neuroblast proliferation
GO:0010001	glial cell differentiation
GO:0035881	amacrine cell differentiation
GO:0043010	camera-type eye development
GO:0045165	cell fate commitment
GO:0045597	positive regulation of cell differentiation
GO:0048666	neuron development
GO:0060041	retina development in camera-type eye

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:108055

InterPro

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
IPR022575 Neurogenic differentiation factor, domain of unknown function

PFAM

PF00010
PF12533

PRINTS

PIRSF

PIRSF015618

SMART

SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt