InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tespa1

Summary

InnateDB Protein

IDBP-199596.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tespa1

Protein Name

RIKEN cDNA 5830405N20 gene

Synonyms

5830405N20Rik; A430001F24Rik; AI450549;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000047284

InnateDB Gene

IDBG-199592 (Tespa1)

Protein Structure

UniProt Annotation

Function

May play a role in the regulation of inositol 1,4,5- trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment (By similarity). Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. {ECO:0000250, ECO:0000269PubMed:22561606}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269PubMed:23650607}. Note=May localize to mitochondria-associated endoplasmic reticulum membrane (MAM). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in lymphoid tissues, with highest expression levels detected in thymus and lower levels in spleen and lymph nodes (at protein level). Detected in CD4(+) and CD8(+) T-cells, B-cells and mast cells. Not detected in monocytes/macrophages. {ECO:0000269PubMed:22561606, ECO:0000269PubMed:23650607}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005102	receptor binding

Biological Process

GO:0010387	COP9 signalosome assembly
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0050862	positive regulation of T cell receptor signaling pathway