InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hic1

Summary

InnateDB Protein

IDBP-199599.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hic1

Protein Name

hypermethylated in cancer 1

Synonyms

AA408311; HIC-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000053483

InnateDB Gene

IDBG-199597 (Hic1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF- responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1. {ECO:0000269PubMed:16269335, ECO:0000269PubMed:18347096}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Note=Defects in Hic1 are the cause of perinatal death with serious developmental anomalies, including acrania, exencephaly, cleft palate, omphalocele, craniofacial and limb anomalies. {ECO:0000269PubMed:10655551}.

Tissue Specificity

Ubiquitously expressed with highest levels in heart and lung. {ECO:0000269PubMed:10655551}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0030178	negative regulation of Wnt signaling pathway