Version 5.4
Mus musculus Protein: Dph1
Summary
InnateDB Protein IDBP-199621.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dph1
Protein Name DPH1 homolog (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000042162
InnateDB Gene IDBG-264528 (Dph1)
Protein Structure
UniProt Annotation
Function Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). Acts also as a tumor suppressor in lung and breast cancers. Plays a role in embryonic growth, organogenesis and postnatal survival. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11527402}. Cytoplasm {ECO:0000269PubMed:11527402}. Note=Punctate, primarily perinuclear localization.
Disease Associations
Tissue Specificity Strongly expressed in kidney and liver. Moderately expressed in brain, skin and testis. Weakly expressed in heart, lung, small intestine, spleen, stomach and thymus. {ECO:0000269PubMed:11527402}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008283 cell proliferation
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2151233
InterPro IPR002728 Diphthamide synthesis, DPH1/DPH2
IPR016435 Diphthamide synthesis, eukaryotic DPH1/archaeal DPH2
PFAM PF01866
PRINTS
PIRSF PIRSF004967
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5NCQ5
PhosphoSite PhosphoSite-Q5NCQ5
TrEMBL
UniProt Splice Variant
Entrez Gene 116905
UniGene
RefSeq NP_652762
MGI ID
MGI Symbol Dph1
OMIM
CCDS CCDS25042
HPRD
IMGT
EMBL AL603905 AY078170 BC044663
GenPept AAH44663 AAM14629 CAI35090

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca