Version 5.4
Mus musculus Protein: Ttll7
Summary
InnateDB Protein IDBP-199660.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttll7
Protein Name tubulin tyrosine ligase-like family, member 7
Synonyms 1110049N09Rik; 4921517B04Rik; C630030B20; Ttll7s;
Species Mus musculus
Ensembl Protein ENSMUSP00000043753
InnateDB Gene IDBG-199614 (Ttll7)
Protein Structure
UniProt Annotation
Function Polyglutamylase which preferentially modifies beta- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for neurite growth. {ECO:0000269PubMed:16901895, ECO:0000269PubMed:17499049}.
Subcellular Localization Cell projection, cilium {ECO:0000269PubMed:16901895, ECO:0000269PubMed:17499049}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:16901895, ECO:0000269PubMed:17499049}. Cell projection, dendrite {ECO:0000269PubMed:16901895, ECO:0000269PubMed:17499049}. Perikaryon {ECO:0000269PubMed:16901895, ECO:0000269PubMed:17499049}. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon. {ECO:0000269PubMed:16901895, ECO:0000269PubMed:17499049}.
Disease Associations
Tissue Specificity Widely expressed with highest levels in brain, testis and trachea. In brain, highly expressed in hippocampus, thalamus, olfactory bulb and cerebellum. {ECO:0000269PubMed:16901895, ECO:0000269PubMed:17499049}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016874 ligase activity
Biological Process
GO:0007399 nervous system development
GO:0018095 protein polyglutamylation
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0030425 dendrite
GO:0043204 perikaryon
Protein Structure and Domains
PDB ID MGI:1918142
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4Q9F0
PhosphoSite PhosphoSite-A4Q9F0
TrEMBL
UniProt Splice Variant
Entrez Gene 70892
UniGene Mm.489431
RefSeq XP_006502149
MGI ID
MGI Symbol Ttll7
OMIM
CCDS
HPRD
IMGT
EMBL AK014905 AK083236 AM690750 AM690751
GenPept BAB29613 BAC38821 CAM84327 CAM84328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca