Version 5.4
Mus musculus Protein: Gas8
Summary
InnateDB Protein IDBP-199683.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gas8
Protein Name growth arrest specific 8
Synonyms Gas11;
Species Mus musculus
Ensembl Protein ENSMUSP00000090730
InnateDB Gene IDBG-199681 (Gas8)
Protein Structure
UniProt Annotation
Function Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility. {ECO:0000269PubMed:11751847, ECO:0000269PubMed:17366626}.
Subcellular Localization Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, flagellum basal body. Golgi apparatus {ECO:0000250}. Note=Associates with microtubules. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa.
Disease Associations
Tissue Specificity Highly expressed in adult testes. Weakly or not expressed in other tested tissues. {ECO:0000269PubMed:11751847}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0017137 Rab GTPase binding
Biological Process
GO:0030317 sperm motility
GO:0034613 cellular protein localization
Cellular Component
GO:0005794 Golgi apparatus
GO:0005874 microtubule
GO:0031514 motile cilium
Protein Structure and Domains
PDB ID MGI:1202386
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60779
PhosphoSite PhosphoSite-Q60779
TrEMBL Q49MD7
UniProt Splice Variant
Entrez Gene 104346
UniGene
RefSeq NP_061343
MGI ID
MGI Symbol Gas8
OMIM
CCDS CCDS40512
HPRD
IMGT
EMBL AY692443 BC003779 CH466525 U19859
GenPept AAA85258 AAH03779 AAW47235 EDL11749

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca