InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mr1

Summary

InnateDB Protein

IDBP-199692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mr1

Protein Name

major histocompatibility complex, class I-related

Synonyms

H2ls;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027744

InnateDB Gene

IDBG-199690 (Mr1)

Protein Structure

UniProt Annotation

Function

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites (By similarity). Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand- dependent. {ECO:0000250, ECO:0000269PubMed:15802267}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed thymus. Expressed in liver, kidney, spleen, heart, brain, lung, skeletal muscle and testis. {ECO:0000269PubMed:12794138, ECO:0000269PubMed:9325151, ECO:0000269PubMed:9780177}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003823	antigen binding
GO:0005515	protein binding
GO:0042605	peptide antigen binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002367	cytokine production involved in immune response
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0032611	interleukin-1 beta production
GO:0032620	interleukin-17 production
GO:0045087	innate immune response
GO:0050829	defense response to Gram-negative bacterium

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0042612	MHC class I protein complex

Protein Structure and Domains

PDB ID

MGI:1195463

InterPro

IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein
IPR027648 MHC class I alpha chain

PFAM

PF00129
PF07654

PRINTS

PR01638

PIRSF

SMART

SM00407

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt